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TriNeuroPlex™ is a product that may provide support to a healthy mood and feeling of well-being. It can be administered in a capsule, tablet, powder or liquid. The recommended serving size for TriNeoroPlex™ is 15 mgs twice daily. The label should include a warning that if anyone has any brain related, medical problems and/or depression they should check with a health care provider before taking product. In addition, Saffron should not be taken with any antidepressants including MAO inhibitors.


Abe K, Saito H. Effects of saffron extract and its constituent crocin on learning behavior and long-term potentiation. Phytother Res. 2000;14(3):149-152.

Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, et al. Crocus sativus L. in the treatment of mild to moderate depression: A double-blind, randomized and placebo-controlled trial Phytother. Res. 2005;19:148–151.

Karimi G, Hosseinzadeh H, Khaleghpanah P. Study of antidepressant effect of aqueous and ethanolic of Crocus sativus in mice. Iran J Basic Med Sci. 2001;4:11–15.

Noorbalaa AA, Akhondzadeha S, Tahmacebi-Poura N, et al. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial. J Ethnopharmacol. 2005;97:281–284.

Srivastava R, Ahmed H, Dixit RK, et al. Crocus sativus L.: A comprehensive review. Pharmacogn Rev. 2010;4(8):

* This content is intended for trade purposes only. The information contained herein is based upon currently available research. It is not intended for use in labeling or marketing to consumers. It may not be copied or disseminated to any third party without the written permission of IN-Ingredients. We strongly recommend seeking counsel for issues dealing with proper labeling and advertising. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.